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Dickey's lab started learning mucin secretion 20 years in the past and Beforehand discovered The real key genes and proteins concerned, demonstrating how synaptotagmin in addition to a SNARE complicated, similar to that located in neurons, contribute to The crucial element means of Ca2+-activated membrane fusion.The latest iteration of your Grand E

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The team focused on blocking a protein called synaptotagmin-two, or Syt2. Syt2 is found over the floor of the granules made up of mucin. Fusion of such granules with the mobile membrane will depend on Syt2 interacting with proteins from the cell membrane.As a result, blocking the action of Syt2 need to prevent sudden huge mucin release without impa

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